✦ LIBER ✦

Dose response and induction of tolerance to the synthetic antigen (T,G)-A–L in adult rabbits

✍ Scribed by M. Sela; Sara Fuchs; Ruth Maron; Bela Gertner

Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 432 KB
Volume: 1
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830010107

No coin nor oath required. For personal study only.

✦ Synopsis

The immunogenicity of the synthetic multichain polypeptide (T,G)-A-L in rabbits was investigated under a variety of conditions. The polymer led t o antibody production with as little as four micrograms in complete Freund's adjuvant per immunization. The pattern of antibody formation as a function of time varied from dose t o dose, the highest initial response corresponding to the lowest dose administered. The synthetic polypeptide was immunogenic also when incorporated in an alum precipitate, but not when injected intravenously in buffered saline. Tolerance t o (T,G)-A-L was produced in adult rabbits upon intravenous injection.

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