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The Induction of the Initiating Phase of Skin Carcinogenesis in the Mouse by Oral Administration of Urethane (Ethyl Carbamate)

✍ Scribed by Haran, Nechama; Berenblum, I

Book ID
109832753
Publisher
Nature Publishing Group
Year
1956
Tongue
English
Weight
762 KB
Volume
10
Category
Article
ISSN
0007-0920

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Mouse skin tumors, benign papillomas, and squamous cell carcinomas (SCCs) were initiated by a single topical application of urethane followed by repeated promotion with 12-0-tetradecanoylphorbol-13-acetate (TPA). Using the NIH 3T3 focus forming assay, dominant transforming activity was detected in D