The Initiation of Tumour Formation by Urethane in the Mouse
β Scribed by Pound, A W
- Book ID
- 109832874
- Publisher
- Nature Publishing Group
- Year
- 1962
- Tongue
- English
- Weight
- 772 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0007-0920
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## Abstract Evidence has been obtained for the reversibility of initiation of carcinogenesis as evoked by 100 ΞΌ 7,12βdimethylbenz (a)anthracene (DMBA) applied to the skin of Swiss mice. Mice exposed to twiceβweekly applications of a phorbol ester, TPA, for 15 weeks developed multiple papillomas whe
Mouse skin tumors, benign papillomas, and squamous cell carcinomas (SCCs) were initiated by a single topical application of urethane followed by repeated promotion with 12-0-tetradecanoylphorbol-13-acetate (TPA). Using the NIH 3T3 focus forming assay, dominant transforming activity was detected in D