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The Initiating Action of Ethyl Carbamate (Urethane) on Mouse Skin

โœ Scribed by Berenblum, I; Haran, Nechama

Book ID
109832718
Publisher
Nature Publishing Group
Year
1955
Tongue
English
Weight
342 KB
Volume
9
Category
Article
ISSN
0007-0920

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Mouse skin tumors, benign papillomas, and squamous cell carcinomas (SCCs) were initiated by a single topical application of urethane followed by repeated promotion with 12-0-tetradecanoylphorbol-13-acetate (TPA). Using the NIH 3T3 focus forming assay, dominant transforming activity was detected in D