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The induction of apoptosis in proliferating human fibroblasts by oxygen radicals is associated with a p53- and p21WAF1CIP1 induction

✍ Scribed by Susanne Gansauge; Frank Gansauge; Heike Gause; Bertram Poch; Michael H Schoenberg; Hans G Beger

Book ID: 117107208
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 514 KB
Volume: 404
Category: Article
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(97)00059-8

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## Abstract Butyric acid is well recognized as a histone deacetylase (HDAC) inhibitor, and changes in histone acetylation are thought to alter gene expression. The mechanism by which sodium butyrate (NaB) induces p21^WAF1/CIP1^, a critical gene involved in the antiproliferative effect of NaB, was s