Induction of apoptosis by human amylin in RINm5F islet β-cells is associated with enhanced expression of p53 and p21WAF1/CIP1
✍ Scribed by Shaoping Zhang; Junxi Liu; ‘Etuate L. Saafi; Garth J.S. Cooper
- Book ID
- 117111164
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 391 KB
- Volume
- 455
- Category
- Article
- ISSN
- 0014-5793
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## Abstract Butyric acid is well recognized as a histone deacetylase (HDAC) inhibitor, and changes in histone acetylation are thought to alter gene expression. The mechanism by which sodium butyrate (NaB) induces p21^WAF1/CIP1^, a critical gene involved in the antiproliferative effect of NaB, was s
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