The incorporation of 5-fluorouracil into RNA of normal tissues and an adenocarcinoma transplanted into the liver of protein deprived rats
✍ Scribed by Stenram, U.; El Hag, I.A.; Christensson, P.-I.; Erichsen, C.; Jakobsson, B.; Jönsson, P.-E.
- Book ID
- 122711934
- Publisher
- Elsevier Science
- Year
- 1987
- Weight
- 118 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0277-5379
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
In a model of secondary liver cancer in Wistar rats the incorporation of 5-FUra into the acid soluble fraction, RNA, and DNA of several normal tissues and of an adenocarcinoma of the colon transplanted to the liver was determined; 300, 1,200 or 24,000 nmoles of 5-FUra were infused via the gastroduod
Background and Objectives: 5-fluorouracil (5-FU) exerts its effects mainly by its incorporation into RNA and inhibition of DNA synthesis. Its toxicity may therefore be estimated by measuring its incorporation into RNA. Protein malnutrition has been considered to increase the toxicity of 5-FU. Method
The cytotoxicity of 5-FUra has been related to its incorporation into RNA. In a model of secondary liver cancer in the rat, the incorporation of 5-FUra into the acid-soluble fraction, RNA and DNA of several normal tissues and an adenocarcinoma of the colon transplanted to the liver was determined. A