Incorporation of pyrimidines and 5-fluoropyrimidines into normal tissues and an adenocarcinoma transplanted into the liver in rat
✍ Scribed by Per Inge Christensson; Christian Erichsen; Per-Ebbe Jönsson; Unne Stenram
- Book ID
- 112295281
- Publisher
- Springer-Verlag
- Year
- 1985
- Tongue
- English
- Weight
- 285 KB
- Volume
- 110
- Category
- Article
- ISSN
- 1432-1335
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📜 SIMILAR VOLUMES
In a model of secondary liver cancer in Wistar rats the incorporation of 5-FUra into the acid soluble fraction, RNA, and DNA of several normal tissues and of an adenocarcinoma of the colon transplanted to the liver was determined; 300, 1,200 or 24,000 nmoles of 5-FUra were infused via the gastroduod
Background and Objectives: 5-fluorouracil (5-FU) exerts its effects mainly by its incorporation into RNA and inhibition of DNA synthesis. Its toxicity may therefore be estimated by measuring its incorporation into RNA. Protein malnutrition has been considered to increase the toxicity of 5-FU. Method