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The impact of a high-frequency microsatellite instability phenotype on the tumor location-related genetic differences in colorectal cancer

✍ Scribed by Yan Zhao; Eiji Oki; Koji Ando; Masaru Morita; Yoshihiro Kakeji; Yoshihiko Maehara


Book ID
113513642
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
271 KB
Volume
196
Category
Article
ISSN
0165-4608

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## Abstract High‐frequency microsatellite instability (MSI‐H) due to defective DNA mismatch repair occurs in the majority of hereditary nonpolyposis colorectal cancers (HNPCCs) and in a subset of sporadic malignant tumors. Clinicopathologic and genotypic features of MSI‐H colorectal tumors in HNPCC