Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study
β Scribed by Hassan Brim; Pooneh Mokarram; Fakhraddin Naghibalhossaini; Mehdi Saberi-Firoozi; Mansour Al-Mandhari; Kamla Al-Mawaly; Rayhaneh Al-Mjeni; Abeer Al-Sayegh; Sandy Raeburn; Edward Lee; Francis Giardiello; Duane T Smoot; Alexander Vilkin; C Richard Boland; Ajay Goel; Mitra Hafezi; Mehdi Nouraie; Hassan Ashktorab
- Book ID
- 119901998
- Publisher
- BioMed Central
- Year
- 2008
- Tongue
- English
- Weight
- 570 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1476-4598
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## Abstract Approximately 1β2% of colorectal cancers (CRC) arise because of germline mutations in DNA mismatch repair genes, referred to as Lynch syndrome. These tumours show microsatellite instability (MSI) and loss of expression of mismatch repair proteins. Preβsymptomatic identification of mutat