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A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency

✍ Scribed by Tian, Sun; Roepman, Paul; Popovici, Vlad; Michaut, Magali; Majewski, Ian; Salazar, Ramon; Santos, Cristina; Rosenberg, Robert; Nitsche, Ulrich; Mesker, Wilma E; Bruin, Sjoerd; Tejpar, Sabine; Delorenzi, Mauro; Bernards, Rene; Simon, Iris

Book ID
118765517
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
267 KB
Volume
228
Category
Article
ISSN
0022-3417

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## Abstract High‐frequency microsatellite instability (MSI‐H) due to defective DNA mismatch repair occurs in the majority of hereditary nonpolyposis colorectal cancers (HNPCCs) and in a subset of sporadic malignant tumors. Clinicopathologic and genotypic features of MSI‐H colorectal tumors in HNPCC