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The genetic basis of negative selection of Tcrb-Vll+T cells

โœ Scribed by Kyuhei Tomonari; Sue Fairchild


Book ID
105287449
Publisher
Springer-Verlag
Year
1991
Tongue
English
Weight
432 KB
Volume
33
Category
Article
ISSN
0093-7711

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Positive and negative selection of Tcrb-
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Tcrb-V6+ T cells are deleted by an endogenous superantigen probably encoded by a mouse mammary tumor provirus (Mtv), Mtv-7, in association with major histocompatibility complex (MHC) class II molecules. In contrast, Tcrb-V6+CD4+ T cells are positively selected by MHC class II E molecules in Mtv-7- m

Positive selection of Tcrb-V10b+T cells
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The Tcrb-V10b+ T cell population has been examined with a newly established antibody, KT10b, specific for Tcrb-V10b but not Tcrb-V10a. H-2E+ mice have higher levels of Tcrb-V10b+ T cells (4.3%-11.0%) than H-2E- mice (2.2%-4.9%). This difference appears to be determined by levels of Tcrb-V10b+ T cell