The Tcrb-V10b+ T cell population has been examined with a newly established antibody, KT10b, specific for Tcrb-V10b but not Tcrb-V10a. H-2E+ mice have higher levels of Tcrb-V10b+ T cells (4.3%-11.0%) than H-2E- mice (2.2%-4.9%). This difference appears to be determined by levels of Tcrb-V10b+ T cell
Positive selection of Tcrb-V4+CD8+T cells by H-2dmolecules
โ Scribed by Kyuhei Tomonari; Sue Fairchild
- Book ID
- 104655715
- Publisher
- Springer-Verlag
- Year
- 1990
- Tongue
- English
- Weight
- 240 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0093-7711
No coin nor oath required. For personal study only.
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Tcrb-V6+ T cells are deleted by an endogenous superantigen probably encoded by a mouse mammary tumor provirus (Mtv), Mtv-7, in association with major histocompatibility complex (MHC) class II molecules. In contrast, Tcrb-V6+CD4+ T cells are positively selected by MHC class II E molecules in Mtv-7- m
Tcrb-V-specific positive and negative selection of T cells has been well documented. In contrast, nothing is known about Tcra-V-specific selection. Using Tcra-V8-specific KT50 antibody Tcra-V8-specific selection of T cells has been examined. The CD8+ T cell subpopulation bearing Tcra-V8 are shown to