T cell activation is negatively regulated by cytotoxic T lymphocyte antigen 4 (CTLA-4) and the killer cell inhibitory receptors. Endocytosis and signaling of CTLA-4 are regulated by tyrosine phosphorylation. While T cell activation is mediated by phosphorylation of immunoreceptor tyrosine-based acti
Aire regulates negative selection of organ-specific T cells
β Scribed by Liston, Adrian; Lesage, Sylvie; Wilson, Judith; Peltonen, Leena; Goodnow, Christopher C.
- Book ID
- 109923565
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 583 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1529-2908
- DOI
- 10.1038/ni906
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