Negative regulation of T cell activation

✍ Scribed by Takashi Saito

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 873 KB
• Volume: 10
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(98)80170-2

✦ Synopsis

T cell activation is negatively regulated by cytotoxic T lymphocyte antigen 4 (CTLA-4) and the killer cell inhibitory receptors. Endocytosis and signaling of CTLA-4 are regulated by tyrosine phosphorylation. While T cell activation is mediated by phosphorylation of immunoreceptor tyrosine-based activation motifs and tyrosine kinases, inhibitory signals are delivered by tyrosine phosphatases. Unresponsiveness is also induced by modulation of signaling components of the T cell receptor complex.