The First Negishi Cross-Coupling Reaction of Two Alkyl Centers Utilizing a Pd−N-Heterocyclic Carbene (NHC) Catalyst †
✍ Scribed by Hadei, Niloufar; Kantchev, Eric Assen B.; O'Brie, Christopher J.; Organ, Michael G.
- Book ID
- 120828035
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 72 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1523-7060
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## Abstract We have developed the first user‐friendly Negishi protocol capable of routinely cross‐coupling all combinations of alkyl and aryl centers. The use of an easily synthesized, air stable, highly active, well‐defined precatalyst PEPPSI‐IPr (**1**; PEPPSI=pyridine‐enhanced precatalyst prepar