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The facile conversion of T-2 toxin and neosolaniol into anguidine

✍ Scribed by Derek W Anderson; Robin M Black; David A Leigh; J.Fraser Stoddart; Nancy E. Williams

Book ID: 104227638
Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 207 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)96175-6

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✦ Synopsis

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T-2 Toxin (5) and neosolaniol ( 6) are readily converted into anguidine 11) by a procedure where deoxygenation at the C-8 position is achieved, after conversion of the 3-TBDMS ether 7 of neosolaniol ( 6) to the 8-bromide 11 for reduction to the anguidine precursor 12.

Amongst the trichothecene group of antibiotics, anguidine (1) is a key compound as a result of its ready conversion lr2 into verrucarol (2) -the

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