Facile One-Pot Conversion of Aldehydes i
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Chill, Samuel T.; Mebane, Robert C.
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Article
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2010
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Taylor and Francis Group
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English
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A facile one-pot synthesis of amides from aldehydes has been developed. This tandem process involves the formation of a nitrile intermediate obtained from the reaction of an aldehyde with hydroxylamine hydrochloride in dimethylsulfoxide at 100 C and the subsequent treatment of the nitrile with basic