Facile One-Pot Conversion of Aldehydes into Amides

✍ Scribed by Chill, Samuel T.; Mebane, Robert C.

• Book ID: 121267455
• Publisher: Taylor and Francis Group
• Year: 2010
• Tongue: English
• Weight: 187 KB
• Volume: 40
• Category: Article
• ISSN: 0039-7911
• DOI: 10.1080/00397910903219443

✦ Synopsis

A facile one-pot synthesis of amides from aldehydes has been developed. This tandem process involves the formation of a nitrile intermediate obtained from the reaction of an aldehyde with hydroxylamine hydrochloride in dimethylsulfoxide at 100 C and the subsequent treatment of the nitrile with basic hydrogen peroxide. The resulting amide products were produced in good yields (67-95%) and purity (>95%).