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A Facile One-Pot Conversion of Aldehydes into Nitriles

โœ Scribed by Chill, Samuel T.; Mebane, Robert C.


Book ID
120813544
Publisher
Taylor and Francis Group
Year
2009
Tongue
English
Weight
215 KB
Volume
39
Category
Article
ISSN
0039-7911

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A facile one-pot synthesis of amides from aldehydes has been developed. This tandem process involves the formation of a nitrile intermediate obtained from the reaction of an aldehyde with hydroxylamine hydrochloride in dimethylsulfoxide at 100 C and the subsequent treatment of the nitrile with basic

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