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The excision of AP sites by the 3'-5' exonuclease activity of the Klenow fragment of Escherichia coli DNA polymerase I

✍ Scribed by Véronique Bailly; Walter G. Verly


Book ID
115915736
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
439 KB
Volume
178
Category
Article
ISSN
0014-5793

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A domain of the klenow fragment of Esche
✍ P. S. Freemont; Dr. D. L. Ollis; T. A. Steitz; C. M. Joyce 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 868 KB

The Klenow fragment of DNA polymerase I from Escherichia coli has two enzymatic activities: DNA polymerase and 3'-5' exonuclease. The crystal structure showed that the fragment is folded into two distinct domains. The smaller domain has a binding site for deoxynucleoside monophosphate and a divalent