A domain of the klenow fragment of Esche
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P. S. Freemont; Dr. D. L. Ollis; T. A. Steitz; C. M. Joyce
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Article
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1986
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John Wiley and Sons
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English
⚖ 868 KB
The Klenow fragment of DNA polymerase I from Escherichia coli has two enzymatic activities: DNA polymerase and 3'-5' exonuclease. The crystal structure showed that the fragment is folded into two distinct domains. The smaller domain has a binding site for deoxynucleoside monophosphate and a divalent