## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t
The Evolving Role of Drug Metabolism in Drug Discovery and Development
โ Scribed by Lilian G. Yengi; Louis Leung; John Kao
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 407 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0724-8741
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Pharmacokinetic data obtained jointly by the drug metabolism group and the pharmaceutical chemist are essential to the selection of the proper dosage form for preclinical and Phase I studies. Subsequent biopharmaceutic studies aid in the development of alternate dosage forms and in devising suitable