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Role of drug metabolism in drug research and development: Basic considerations

โœ Scribed by John E. Baer

Publisher
John Wiley and Sons
Year
1972
Tongue
English
Weight
445 KB
Volume
61
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

โœฆ Synopsis

Data from the rapid systematic study of the fate of a new drug in rats and dogs can aid the design of pharmacological and safety tests and can provide a basis for biopharmaceutic and Phase I clinical trials. Keyphrases Drug metabolism-role in drug research and development, symposium Biopharmaceutics-drug metabolism in rats and dogs, design of pharmacological and safety tests 0 Metabolism, drug-species dependence, design of pharmacological and safety tests * Reference I I and unpublished observations. b Separate experiments were performed to determine biliary excretion. The interspecies differences in composition of the 'C-substances are under continumg study. c 1 mg./kg. s.c.; 2-hr. sample. d -0.5 mg./kg.; 48-hr. urine, 96-hr. stool.

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