Role of drug metabolism in drug research and development: View of a medicinal chemist
โ Scribed by Frank H. Clarke
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 467 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
โฆ Synopsis
This short review is an attempt to illustrate, with a few specific examples, how useful the results of drug metabolism studies are to the medicinal chemist who is seeking to improve the physiological properties of a potential new medicinal agent. The medicinal chemist must keep abreast of the studies of his associates who are evaluating his new compound as a potential drug. Only with close cooperation and teamwork among all concerned will the full potential of the new discoveries of medicinal chemistry be realized.
Keyphrases
Drug metabolism-role in drug research and development, symposium 0 Medicinal chemists-use of drug metabolism studies to design and synthesize potential new drugs 0 Development of new drugs-use of drug metabolism studies by medicinal chemists It is the responsibility of the medicinal chemist to design and synthesize potential new drugs. Usually he baycaine
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## Abstract Metabolism by the host organism is one of the most important determinants of the pharmacokinetic profile of a drug. High metabolic lability usually leads to poor bioavailability and high clearance. Formation of active or toxic metabolites will have an impact on the pharmacological and t