This double-blind, placebo-controlled, crossover study examined the effects of two single doses of eptastigmine, a novel cholinesterase inhibitor, on scopolamine-induced cognitive deficits in 24 healthy male volunteers. Each subject received the following treatment sequences, separated by at least 1
The effects of stimulant and tranquilizer placebos on healthy subjects in a real-life situation
β Scribed by Donald W. Brodeur
- Publisher
- Springer
- Year
- 1965
- Tongue
- English
- Weight
- 510 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
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Single oral doses of lofepramine (140 mg), maprotiline (100 mg), and placebo were administered in a randomized three-way crossover design with 1 week wash-out between administrations to 12 healthy male volunteers. Before, and 1, and 3 h post-administration a battery of performance tests was administ
## Abstract ## Objective To assess the effects of antidepressants on driving performance from a different methodological viewpoint in light of the recent traffic accidents. ## Methods In this doubleβblinded, 3βway crossover trial, 17 healthy males received acute doses of 10βmg paroxetine, 25βmg