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A comparison of the effect of lofepramine, maprotiline and placebo on information processing in healthy volunteers

✍ Scribed by H. Hopes; J. Wandmacher

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 615 KB
Volume: 7
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470070305

No coin nor oath required. For personal study only.

✦ Synopsis

Single oral doses of lofepramine (140 mg), maprotiline (100 mg), and placebo were administered in a randomized three-way crossover design with 1 week wash-out between administrations to 12 healthy male volunteers. Before, and 1, and 3 h post-administration a battery of performance tests was administered which included a digit-matching paradigm and a reaction test separating recognition and motor time. In contrast to maprotiline, lofepramine did not impair speed and accuracy of cognitive performance.

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