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Comparison of the effects of fengabine, a novel antidepressant, with those of amitriptyline on psychomotor and autonomic functions in healthy volunteers

✍ Scribed by N. Theofilopoulos; C. M. Gray; E. Szabadi; C. M. Bradshaw

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 553 KB
Volume: 4
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470040208

No coin nor oath required. For personal study only.

✦ Synopsis

Two single doses (300 and 600 mg) of fengabine, a novel antidepressant, a single dose (50 mg) of amitriptyline, and a single dose of placebo were taken by sixteen male healthy volunteers (18-30 years), in weekly experimental sessions, according to a balanced double-blind cross-over design. In Part A (eight subjects) subjective mood state, psychomotor performance and some baseline autonomic functions were measured before, and 1,3 and 5 hours after drug taking. In Part B, cholinoceptor-mediated tissue responses (pilocarpine-evoked miosis and carbachol-evoked sweating) were measured two and a half hours after drug taking. Fengabine and placebo did not affect any of the test results, whereas amitriptyline had effects consistent with the sedative (reduction in alertness, impairment of psychomotor performance) and antimuscarinic (reduction in salivation and carbachol-evoked sweating) properties of the drug. KEY woms-Fengabhe, amitriptyline, psychomotor functions, autonomic functions.

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