## Abstract Regulatory T cells (Treg cells) have been well documented to have a crucial physiological role in preventing the development of autoimmune diseases and keeping self‐tolerance. Foxp3, a recently identified member of the forkhead transcription factors, serves as a master regulator for the
The effects of leflunomide on CD4+CD25+Foxp3+T regulatory cells in mice receiving allogeneic bone marrow transplantation
✍ Scribed by Di Jin; Kaizhong Duan; Lianjun Zhang; Jianxia Peng; Yong Zhao
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 2011
- Tongue
- English
- Weight
- 497 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1420-908X
No coin nor oath required. For personal study only.
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the authors want to correct the Methods section regarding the fixation/permeabilization protocols used for this study. The authors mentioned the use of 4% paraformaldehyde (PFA) on pages 2 and 3 to resuspend the cells lasting the final step before flow acquisition, when in reality 1% PFA was used. F
The transcription factor FOXP3 plays a key role in CD4 + CD25 + regulatory T cell function and represents a specific marker for these cells. Despite its strong association with regulatory T cell function, in humans little is known about the frequency of CD4 + CD25 + cells that express FOXP3 protein