T cell receptor repertoire of CD4+and CD8+T cell subsets in the allogeneic bone marrow transplant recipient
β Scribed by F. Suzette Smith; Samantha D. Rencher; Helen E. Heslop; Julia L. Hurwitz
- Publisher
- Springer-Verlag
- Year
- 1995
- Tongue
- English
- Weight
- 583 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0340-7004
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The antigenic specificity of the majority of T lymphocytes in the peripheral blood is determined by the combination of a and p variable region chains present in the T cell receptor complex. Currently, the Vp chains are grouped into 25 families. Historically, determination of Vp usage has relied on d
CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta