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The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells

✍ Scribed by Jacqueline P. Law; Dale F. Hirschkorn; Rachel E. Owen; Hope H. Biswas; Philip J. Norris; Marion C. Lanteri


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
568 KB
Volume
75A
Category
Article
ISSN
0196-4763

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The transcription factor FOXP3 plays a key role in CD4 + CD25 + regulatory T cell function and represents a specific marker for these cells. Despite its strong association with regulatory T cell function, in humans little is known about the frequency of CD4 + CD25 + cells that express FOXP3 protein