Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood
โ Scribed by Xin Chen; Jeffrey J. Subleski; Ryoko Hamano; O. M. Zack Howard; Robert H. Wiltrout; Joost J. Oppenheim
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 354 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0014-2980
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The transcription factor FOXP3 plays a key role in CD4 + CD25 + regulatory T cell function and represents a specific marker for these cells. Despite its strong association with regulatory T cell function, in humans little is known about the frequency of CD4 + CD25 + cells that express FOXP3 protein
the authors want to correct the Methods section regarding the fixation/permeabilization protocols used for this study. The authors mentioned the use of 4% paraformaldehyde (PFA) on pages 2 and 3 to resuspend the cells lasting the final step before flow acquisition, when in reality 1% PFA was used. F
## Background: Cd4+cd25+ regulatory t cells (tr) can prevent or treat experimental murine colitis but little is known about their potential role in human inflammatory bowel disease (ibd). foxp3 is a transcription factor that plays a critical role in the development and function of cd4+cd25+ tr. the
## Abstract Regulatory T cells (Treg cells) have been well documented to have a crucial physiological role in preventing the development of autoimmune diseases and keeping selfโtolerance. Foxp3, a recently identified member of the forkhead transcription factors, serves as a master regulator for the