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The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

✍ Scribed by Gomez, Denise Y.; Wacher, Vincent J.; Tomlanovich, Stephen J.; Hebert, Mary F.; Benet, Leslie Z.

Publisher: Nature Publishing Group
Year: 1995
Tongue: English
Weight: 527 KB
Volume: 58
Category: Article
ISSN: 0009-9236
DOI: 10.1016/0009-9236(95)90067-5

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Abbreviations: AUC, area under the curve; AUC 0-1 , area under the curve from time 0 to infinity; CI, confidence interval(s); CL/F, apparent clearance; C max , maximum concentration; CRU, Clinical Research Unit; CYP3A, cytochrome P450 3A; DN, dose-normalized; F, oral bioavailability; GLS mean ratio(