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Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus

✍ Scribed by Varun Garg; Rolf van Heeswijk; Jee Eun Lee; Katia Alves; Priya Nadkarni; Xia Luo

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 160 KB
Volume: 54
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.24443

No coin nor oath required. For personal study only.

✦ Synopsis

Abbreviations: AUC, area under the curve; AUC 0-1 , area under the curve from time 0 to infinity; CI, confidence interval(s); CL/F, apparent clearance; C max , maximum concentration; CRU, Clinical Research Unit; CYP3A, cytochrome P450 3A; DN, dose-normalized; F, oral bioavailability; GLS mean ratio(s), geometric least squares mean ratio(s); HCV, hepatitis C virus; k z , terminal elimination rate constant; P-gp, p-glycoprotein; PK, pharmacokinetic(s); q8h, every eight hours; t ½ , terminal elimination half-life; t max , time to reach maximum concentration; V z /F, apparent volume of distribution.

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