✦ LIBER ✦

The effect of food on ciramadol bioavailability in normal subjects

✍ Scribed by Dr P. R. Audet; S. Chiang; A Maroli; A. Locniskar; G. Morrison

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 274 KB
Volume: 8
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510080310

No coin nor oath required. For personal study only.

✦ Synopsis

Eleven healthy volunteers completed a study to compare the relative bioavailability to orally administered ciramadol in a fasting versus postprandial state. A single oral dose of 30mg of ciramadol was administered on two separate occasions, 2 weeks apart, in a randomized crossover study. A mono-or biexponential pharmacokinetic equation with first-order absorption was applied to analyse the serum data for each subject. Significant differences were found in peak time (tmax) and absorption time (tabs) whereas the mean AUCs for the two modes of administration were not significantly different. The relative bioavailability (F) of the drug when administered in the postprandial state with respect to the fasting state was 96 per cent. It is thus concluded that ingestion of food has no effect on the extent of absorption of ciramadol; however, food may alter its rate of absorption.

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