✦ LIBER ✦

The effect of food on the relative bioavailability of fadrozole hydrochloride

✍ Scribed by R. Leslie Choi; Jim X. Sun; Gregory M. Kochak

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 342 KB
Volume: 14
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510140904

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of food on the pharmacokinetic disposition of fadrozole hydrochloride was evaluated in nine healthy male and female volunteers. Single 12 mg doses of fadrozole were orally administered to subjects immediately following a standardized meal or after fasting for 12 h, in a randomized crossover design. No statistically significant treatment differences were detected for the pharmacokinetic parameters AUC and half-life. C,, was significantly reduced by 15% for the fed treatment relative to the fasted treatment, and tam was delayed by 39%. These findings indicate that the concomitant ingestion of food with fadrozole delays the gastric emptying and/or absorption of fadrozole, but has no effect on the extent of absorption.

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