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The effect of experimental cryptorchism on the isozymes of lactate dehydrogenase in mouse testes

✍ Scribed by Goldberg, Erwin ;Hawtrey, Christopher

Publisher
John Wiley and Sons
Year
1968
Tongue
English
Weight
831 KB
Volume
167
Category
Article
ISSN
0022-104X

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✦ Synopsis

Unilateral cryptorchism produced by experimental retention of one testis in the abdomen of the mouse results in a rapid decrease in the weight of that testis. At the same time the specific activity of lactate dehydrogenase (LDH) decreases to 70% of the normal value. The sperm-specific isozyme, LDH-X, declines from 41% of the total activity to only 16% after eleven days in the abdomen. All LDH-X activity is lost by post-operative day 24. The relative proportion of the other isozymes of LDH increase following the operation. LDH-5, absent from the mature testis, is detectable in the cryptorchid testis at post-operative day 28 and represents 15% of the total LDH activity. These observations provide further support to the suggestion that LDH-X is only found in the testes when meiosis is occurring.

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