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The effect of (±)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze

✍ Scribed by Martin R. Guscott; Hannah F. Clarke; Fraser Murray; Sarah Grimwood; Linda J. Bristow; Peter H. Hutson


Book ID
114015889
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
322 KB
Volume
476
Category
Article
ISSN
0014-2999

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## Abstract Glutamate antagonists decrease dyskinesia and augment the antiparkinsonian effects of levodopa in animal models of Parkinson's disease (PD). In a randomized, double‐blind, placebo‐controlled clinical trial, we investigated the acute effects of placebo and two doses of a NR2B subunit sel