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Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist

✍ Scribed by Kana Taniguchi; Katsuhiro Shinjo; Mayumi Mizutani; Kaoru Shimada; Toshihisa Ishikawa; Frank S. Menniti; Atsushi Nagahisa


Book ID
110003226
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
297 KB
Volume
122
Category
Article
ISSN
0007-1188

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## Abstract Glutamate antagonists decrease dyskinesia and augment the antiparkinsonian effects of levodopa in animal models of Parkinson's disease (PD). In a randomized, double‐blind, placebo‐controlled clinical trial, we investigated the acute effects of placebo and two doses of a NR2B subunit sel