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The Effect of ABCG2 and ABCC4 on the Pharmacokinetics of Methotrexate in the Brain

✍ Scribed by Sane, R.; Wu, S.-P.; Zhang, R.; Gallo, J. M.


Book ID
121861014
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2014
Tongue
English
Weight
755 KB
Volume
42
Category
Article
ISSN
0090-9556

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## Abstract The interaction between indomethacin (IND) and methotrexate (MTX) was investigated in rabbits. The study was designed so as to evaluate the effect of IND (1 mg h^βˆ’1^) during a continuous MTX infusion (1Β·2 mg kg^βˆ’1^) over 240 min. IND was injected i.v. at hourly intervals after a steady