𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of X-irradiation on the pharmacokinetics of methotrexate in rats: Alteration of the blood-brain barrier

✍ Scribed by Van Der Kogel, Albert J.; Nooter, Kees; Storm, Arthur J.

Book ID
123082771
Publisher
Elsevier Science
Year
1985
Weight
579 KB
Volume
21
Category
Article
ISSN
0277-5379

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

The effect of photon irradiation on bloo
The effect of photon irradiation on blood-brain barrier permeability to methotrexate in mice
✍ Thomas W. Griffin; Janet S. Rasey; W. Archie Bleyer πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 English βš– 241 KB πŸ‘ 3 views

Methotrexate was administered by intraperitoneal injection (100 mg/kg) to unirradiated mice, and to mice receiving varying doses of cranial irradiation. The animals were sacrificed 24 hours after injection, and methotrexate assays were performed on brain tissue. No methotrexate was detected in the

Pharmacokinetics of P-glycoprotein inhib
Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier
✍ Stina SyvΓ€nen; Andrew Hooker; Obaidur Rahman; Helena Wilking; Gunnar Blomquist; πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 338 KB

This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded