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The Effect of Cranial Irradiation on Blood-Brain Barrier Permeability to Methotrexate

✍ Scribed by R. S. SESHADRI; R. G. RYALL; M. S. RICE; MARGARET LEAHY; R. ELLIS

Book ID
118705429
Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
226 KB
Volume
15
Category
Article
ISSN
1034-4810

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Methotrexate was administered by intraperitoneal injection (100 mg/kg) to unirradiated mice, and to mice receiving varying doses of cranial irradiation. The animals were sacrificed 24 hours after injection, and methotrexate assays were performed on brain tissue. No methotrexate was detected in the