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The effect of high energy electron irradiation on blood-brain barrier permeability to haloperidol and stobadin in rats

✍ Scribed by T. Trnovec; K. Volenec; Š. Bezek; Z. Kállay; M. Ďurišová; V. Ščasnár; M. Kubu; V. Svoboda

Publisher
Springer-Verlag
Year
1991
Tongue
English
Weight
631 KB
Volume
30
Category
Article
ISSN
0301-634X

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Methotrexate was administered by intraperitoneal injection (100 mg/kg) to unirradiated mice, and to mice receiving varying doses of cranial irradiation. The animals were sacrificed 24 hours after injection, and methotrexate assays were performed on brain tissue. No methotrexate was detected in the