Effect of cefoperazone on the pharmacokinetics of methotrexate in the rabbit
β Scribed by Tawfeeg A.O. Najjar
- Book ID
- 113368281
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 316 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0378-5173
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## Abstract The interaction between indomethacin (IND) and methotrexate (MTX) was investigated in rabbits. The study was designed so as to evaluate the effect of IND (1 mg h^β1^) during a continuous MTX infusion (1Β·2 mg kg^β1^) over 240 min. IND was injected i.v. at hourly intervals after a steady
In rabbits the IV kinetics of MTX (1.33, 4 and 12 mg/kg) could be described by a linear three-compartment model with a terminal half-life between 2.4 and 3.6 h. During 8 h 50% of the dose was excreted into urine in unchanged form and 15% as the metabolite 7-OH-MTX. These fractions remained constant