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Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo

✍ Scribed by Christopher R. Hill; David Jamieson; Huw D. Thomas; Colin D.A. Brown; Alan V. Boddy; Gareth J. Veal


Book ID
119194855
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
988 KB
Volume
85
Category
Article
ISSN
0006-2952

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## Abstract Docetaxel is one of the most widely used anticancer drugs. A major problem with docetaxel treatment, however, is the considerable interpatient variability in docetaxel exposure. Another disadvantage of the drug is that it has a very low oral bioavailability and can, therefore, only be a