𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The distribution of structures in evolving protein populations

✍ Scribed by Darin M. Taverna; Richard A. Goldstein

Publisher
Wiley (John Wiley & Sons)
Year
2000
Tongue
English
Weight
97 KB
Volume
53
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

Proteins exhibit a nonuniform distribution of structures. A number of models have been advanced to explain this observation by considering the distribution of designabilities, that is, the fraction of all sequences that could successfully fold into any particular structure. It has been postulated that more designable structures should be more common, although the exact nature of this relationship has not been addressed. We find that the nonuniform distribution of protein structures found in nature can be explained by the interplay of evolution and population dynamics with the designability distribution. The relative frequency of different structures has a greater-thanlinear dependence on designability, making the distribution of observed protein structures more uneven than the distribution of designabilities. The distribution of structures is also affected by additional factors such as the topology of the sequence space and the similarity of other structures.

πŸ“œ SIMILAR VOLUMES

Population structure increases the evolv
Population structure increases the evolvability of genetic algorithms
✍ Felix J. H. Hol; Xin Wang; Juan E. Keymer πŸ“‚ Article πŸ“… 2012 πŸ› John Wiley and Sons 🌐 English βš– 483 KB πŸ‘ 1 views

## Abstract Populations are shaped by the spatial structure of their environment: space organizes interactions between individuals locally, and gives rise to a global population structure. Both local and global population structures can have a profound influence on the evolutionary dynamics of a po

Genetic distance in sequence space of ev
Genetic distance in sequence space of evolving populations
✍ Elisangela Ferretti Manffra; Holger Kantz; Mario Ragwitz πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 183 KB

## Abstract A genome‐based measure for the distance between two populations is introduced. It fulfills the triangular inequality and can be easily computed, when the genetic sequences of a large number of individuals in two different populations are given. We use this distance for a study of mutati

Distribution of plasminogen allotypes in
Distribution of plasminogen allotypes in eight populations of the Western Hemisphere
✍ Dale Dykes; Mary Nelson; Herbert Polesky πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 English βš– 435 KB

## Abstract Phenotyping for plasminogen (PLG) variants on 0.5 mm agarose isoelectric focusing gels enabled us to identify six different allotypes among the eight populations studied. PLG \*1 and PLG \*2 were seen at polymorphic frequencies in all the populations studied except Eskimos which had a g