✦ LIBER ✦

The Discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

✍ Scribed by Jeffrey T. Kohrt; Christopher F. Bigge; John W. Bryant; Agustin Casimiro-Garcia; Liguo Chi; Wayne L. Cody; Tawny Dahring; Danette A. Dudley; Kevin J. Filipski; Staci Haarer; Ron Heemstra; Nancy Janiczek; Lakshmi Narasimhan; Thomas McClanahan; J. Thomas Peterson; Vaisheli Sahasrabudhe; Robert Schaum; Chad A. Van Huis; Kathleen M. Welch; Erli Zhang; Robert J. Leadley; Jeremy J. Edmunds

Book ID: 111368442
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 922 KB
Volume: 70
Category: Article
ISSN: 1747-0277
DOI: 10.1111/j.1747-0285.2007.00539.x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Discovery of a Fact

ChemInform Abstract: Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic Acid 3-[(5-Chloro-pyridin-2-yl)-amide] 4-{[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a Clinical Candidate.

✍ Wolfgang Haap; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 23 KB 👁 2 views

## Abstract Compound (I) is found to be a potent, selective and orally bioavailable fXa inhibitor based on a pyrrolidine scaffold.

Discovery of (1R,2R)-N-(4-(6-isopropylpy

Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator

✍ Hao, Junliang; Dehlinger, Veronique; Fivush, Adam M.; Rudyk, Helene C.E.; Britto 📂 Article 📅 2013 🏛 Elsevier Science 🌐 English ⚖ 452 KB

Kinesin Spindle Protein (KSP) Inhibitors

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2 S )-4-(2,5-Difluorophenyl)- N -[(3 R ,4 S )-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)- N -methyl-2-phenyl-2,5-dihydro-1 H -pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

✍ Cox, Christopher D.; Coleman, Paul J.; Breslin, Michael J.; Whitman, David B.; G 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 1010 KB

Discovery of 1-(3‘-Aminobenzisoxazol-5‘-

Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

✍ Quan, Mimi L.; Lam, Patrick Y. S.; Han, Qi; Pinto, Donald J. P.; He, Ming Y.; Li 📂 Article 📅 2005 🏛 American Chemical Society 🌐 English ⚖ 319 KB

Discovery of 4-{4-[3-(Pyridin-2-yl)-1 H

Discovery of 4-{4-[3-(Pyridin-2-yl)-1 H -pyrazol-4-yl]pyridin-2-yl}- N -(tetrahydro-2 H - pyran-4-yl)benzamide (GW788388): A Potent, Selective, and Orally Active Transforming Growth Factor-β Type I Receptor Inhibitor

✍ Gellibert, Françoise; de Gouville, Anne-Charlotte; Woolven, James; Mathews, Neil 📂 Article 📅 2006 🏛 American Chemical Society 🌐 English ⚖ 561 KB

Discovery of 1-(2-Aminomethylphenyl)-3-t

Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl- N - [3-fluoro-2‘-(aminosulfonyl)[1,1‘-biphenyl)]-4-yl]-1 H -pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor 1

✍ Pruitt, James R.; Pinto, Donald J. P.; Galemmo,, Robert A.; Alexander, Richard S 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 555 KB