ChemInform Abstract: Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic Acid 3-[(5-Chloro-pyridin-2-yl)-amide] 4-{[2-Fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a Clinical Candidate.

✍ Scribed by Wolfgang Haap; et al. et al.

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 23 KB
• Volume: 42
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201102210

✦ Synopsis

Abstract

Compound (I) is found to be a potent, selective and orally bioavailable fXa inhibitor based on a pyrrolidine scaffold.