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The determination of enantiomeric composition of methamphetamine by 1H-NMR spectroscopy

โœ Scribed by T.C. Kram; I.S. Lurie

Book ID
103902193
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
485 KB
Volume
55
Category
Article
ISSN
0379-0738

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โœฆ Synopsis

The enantiomeric characterization of methamphetamine is readily accomplished by 'H-NMR analysis of the diastereomers formed by derivatization with 2,3,4,6-tetra-O-acetylcetyl-8-D glucopyranosyl isothiocyanate (GITC). The stereospecific chemical shifts of a host of signals from the GITC moiely provide sites for both qualitative and quantitative consideration. These shifts were found to be unsffected over a wide range of product concentration. Further, experimental data indicate a lack of stereoselectivity in the formation of these diastereomers. Application of the technique to a commercial (-)methamphetamine inhalant, previously analyzed by HPLC, confirmed both the presence and proportion of (+)methamphetamine, a controlled substance.

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