✦ LIBER ✦

The design and synthesis of non-peptide ligands with affinity and selectivity for tachykinin receptors

✍ Scribed by David C. Horwell; Andrew I. Morrell; Edward Roberts

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 112 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00582-e

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✦ Synopsis

2,4-disubstituted morpholin-3-one based ligands which show affinity for tachykinin receptors have been designed and synthesised. Variation of the side chains attached to the central template gives rise to selectivity between receptor subtypes. This selectivity is directly analogous to that exhibited by dipcptide ligands for the same receptor subtypes.

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